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Chimeric Therapeutics Reports Good Data in Second Patient Cohort

Chimeric Therapeutics (CHM: $0.21) has finished dosing the second cohort of three patients in its chlorotoxin CAR-T cell therapy in patients with glioblastoma.



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The second cohort of patients received the once-off therapy at twice the dose (88 x 106 cells) to the first cohort of patients. In the first cohort, three of the four patients achieved disease stability at eight weeks. In the current cohort, two of the three patients achieved locally stable disease.

Safety of the therapy remains good, with this second cohort receiving the cells directly into the tumours but also in the CSF (intraventricular injection).

The company will now move on to the third cohort, whereby the dose will be increased by 150% to 220 x 106 cells. Progress of patients from the first cohort would also be beneficial information to investors.

Chimeric Therapeutics is capitalised at $70 million.

Bioshares Recommendation: Speculative Buy Class B


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